Eyes, Inflammation, and all that Jazz
Read All About It
I HAVE A NEW HIP!
Well, not that recent news. I underwent a right total hip replacement on 4th April 2017 and made a full recovery. Many thanks to the skill and kindness of surgeon Prof. Damian Griffin, Anaesthetist Matthew Wyse, all staff on Charlecote Suite and Physios Caroline and Jake at BMI Meriden, Coventry, and Physio David at BMI Priory.
OUT OF THE BLUE BIG BAND
OOTB wowed them at Solihull Methodist Church 7th December 2019 with singer Jan Harris again stealing the limelight (picture from Himley Hall and Park gig May 2019) .
THE SOUL PROVIDERS
TSP go down a storm at Edgbaston Park Hotel, Birmingham on 6th December 2019.
MY ‘NEW' BABY IS DOING WELL!
What's that coming over the hill, is it a Boxster?
Yes, it’s a Boxster!
WELCOME TO MY WEBSIGHT
Just a little bit about me (well, I'm not going to tell you everything!)
I am Professor of Ophthalmology, University of Birmingham and Honorary Consultant Ophthalmologist, Birmingham and Midland Eye Centre, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust.
Born a cockney (within the sound of Bow Bells), but was brought up in West London. Educated at Latymer Upper School (click here for some notable Old Latymerians). Qualified in medicine from St. George's Hospital Medical School, London. Pursued a career in Ophthalmology with Registrar and Senior Registrar posts at Moorfields Eye Hospital, London. Spent one year on sabbatical in Amsterdam at the Department of Ophthalmo-Immunology, Netherlands Ophthalmic Research Institute. Senior Lecturer then very briefly Reader in Ophthalmology in Birmingham. Over many years have 'acquired' two daughters Hannah and Ella, a wife (Tricia), and a PhD but not necessarily in that order. Living in Moseley Village (a suburb of Birmingham, UK) that in 2015 was described by the Sunday Times as the best place to live in Britain and in 2017 as the best place to live in Birmingham. Moseley has an award winning Farmers' Market (it recently won Best Farmers' Market in the UK for the 3rd time!), the Mostly Jazz, Funk & Soul Festival, the Moseley Folk Festival (see some great pics here) and Moseley in Bloom. Sometimes I can be found here.
ACADEMIC UNIT OF OPHTHALMOLOGY (AUO)
The AUO is part of the Centre for Translational Inflammation Research, Institute of Inflammation and Ageing (Head: Prof Janet Lord), College of Medical and Dental Sciences (Head: Prof. David Adams), of the University of Birmingham, UK. We also form part of the Neuroscience and Ophthalmology group.
Our group includes: myself, Si Rauz (Clinical Reader), Alastair Denniston (Hon. Professor), Graham Wallace (Non-clinical Senior Lecturer), Rob Barry (Clinical Senior Lecturer), Jose Romero (Non-clinical Lecturer), Jesse Panthagani (Clinical Lecturer and MD student), Anisha Sekaran (Junior Research Fellow), Clinical PhD students - Liying Low, Gibran Butt, Non-clinical PhD student - Mariam Murad, Charlotte Harris (Secretary). Also Immunosuppression Nurse Practitioner Nat Poonit, Behçet Centre Manager Debbie Mitton, Behçet co-ordinator Vicky Sewell, Research Nurses and Research Data Co-ordinator.
We are based on the 1st Floor of the Birmingham and Midland Eye Centre (BMEC) on the site of City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, and in the Research Laboratories of the Centre for Translational Inflammation Research at the new Queen Elizabeth Hospital, Edgbaston, Birmingham.
To see our publications please use PubMed and search on: murray pi, rauz s, denniston a, wallace gr, barry rj, romero j.
WHAT IS UVEITIS?
Uveitis is a name given to inflammation inside the eye that in some patients can lead to blindness. It can affect one or both eyes and the inflammation involves the uveal tract (iris, ciliary body, and choroid), although inflammation of adjacent tissues, such as vitreous humour, retina, and optic nerve also occurs.
Little is known about the causes of uveitis, but in cases of endogenous uveitis in which no link with an infectious agent can be identified, abnormalities of immune regulation have been invoked as the cause. Many cases are often labelled as idiopathic, but in some they may be part of systemic disease process, such as sarcoidosis, multiple sclerosis, and Behçet’s disease, or associated with the HLA-B27 positive group of diseases. Infectious agents, such as the herpes group of viruses, toxoplasma gondii, mycobacterium tuberculosis, and treponema pallidum are also well-recognised causes.
The incidence of uveitis varies from 14 to 52.4/100,000 with the overall prevalence around the world up to 0.73%. In about half the patients the age of onset is in the third or fourth decade of life, so they are presenting at an age where they are in the most active period of their working life. This age distribution makes uveitis a group of ocular diseases with an important socioeconomic impact. There is a specific sub-group in children that is associated with juvenile idiopathic arthritis.
Many cases will resolve rapidly, some may have repeated attacks in one or both eyes, but a significant number of patients develop persistent disease with inflammatory damage to ocular structures resulting in severe visual impairment. The main causes of sight loss are cystoid macular oedema, cataract, and glaucoma.
Approximately 5-20% of legal blindness in developed countries is due to uveitis, and it has been estimated that uveitis accounts for 10-15% of all cases of total blindness in the USA. Acute anterior uveitis is the commonest subtype and carries the best visual outcome, with a worse visual prognosis seen in patients with posterior uveitis and panuveitis where the back of the eye is involved.
In non-infectious causes, therapy is usually aimed at dampening down the immune response with corticosteroids being the first line treatment. For anterior uveitis eye drops are often the mainstay of treatment, but in sight threatening disease corticosteroid tablets then immunosuppressive agents and biologics may be required to improve or preserve sight.
A selection of sopranos, altos, tenor and baritones.
(I might have a cheap alto and tenor lying around as well!)